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Onset of GVHD defined as urine staining and weight loss of 20% or weight loss of 1015% if accompanied by hunched posture, laboured breathing or poor body condition

Prodrug is one of the main methods to achieve controlled drug release, which can be converted into active drugs through chemical or enzymatic degradation [52, 53].They are activated in response to specific stimuli in the tumor microenvironment, enabling precise targeting of tumor cells while protecting normal tissue from damage

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Similarly, in a comparable RCT involving 30 individuals with CFC, the effectiveness of acupuncture was evaluated against that of sham acupuncture [138]