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In addition, lactate-induced lactylation stabilizes HIF-1 under normoxic conditions, facilitating its transcriptional activity on angiogenic targets (KlAA1199 axis) in prostate cancer cells and contributing to vascular remodeling [93]

(B) THP-1 M0 macrophages treated with HSA, LPS+IFN- (i.e., M1 macrophages), IL4+IL13 (i.e., M2 macrophages), 1 g/mL HBeAg, HBsAg or HBcAg for 48 hours were analyzed by RT-qPCR for the expression of mitochondrial genes, DAP3 and IL-1