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Experiments have shown that overexpression of BECN1 significantly increases levels of malondialdehyde (MDA), Fe 2+ , and ROS in cells, promoting the occurrence of ferroptosis induced by CaOx crystals

Inflammation, steatosis, ballooning, and fibrosis are the features of non-alcoholic fatty liver disease (NAFLD), and the associated critical bona fide genes such as MCP-1, TNF, TNFR1, TGF1, Col1, SMA, Timp1, and Hp were significantly enriched in the livers of mice fed an HFD

Proc Natl Acad Sci USA 2009