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Conventional treatments address either the bone or the surrounding soft tissue, rarely both simultaneously

[DOI] [PMC free article] [PubMed] [Google Scholar] 238.Ota Y., Kawaguchi Y., Takagi K., Ichida H., Gono T., Hanaoka M., Higuchi T., Yamanaka H

While SCLC is mostly chemosensitive in frontline therapy, the inevitable disease relapse in most patients and the subsequent chemoresistance remain formidable problems leading to very poor overall outcome (Ma and Salgia, 2004)

The carbon dioxide variant caused wound contraction, induced collagen remodeling, activated fibroblast growth factor, and reduced transforming growth factor beta