anemias due to disorders of glutathione metabolism Frontiers Glutathione Metabolism - an overview

Contraindications and cautions include asthma (glutathione may trigger bronchospasm in sensitive individuals), platinum-based chemotherapy (glutathione may reduce drug efficacy), and certain genetic variations affecting cysteine and sulfur metabolism

To achieve this, there can be only two possibilities: (i) tumor cells may exhibit mechanism(s) removing malonyl-CoA but without directing it toward the fatty acyl synthase machinery, thus relieving carnitine palmitoyltransferase 1 inhibition, and/or (ii) cancers harbor a carnitine palmitoyltransferase 1 that is not sensitive to inhibition by malonyl-CoA

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Additional information Edited by M Piacentini Supplementary Information accompanies this paper on Cell Death and Disease website Supplementary information Rights and permissions This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License