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Leukemia 25:473478 Scheinberg M, Machado LA, Castro LGM, Ferreira SB, Michalany N (2021) Successful treatment of ulcerated pyoderma gangrenosum with baricitinib, a novel JAK inhibitor

Increased PARP2 , a consuming NAD+ enzyme, can inhibit SIRT1 levels, therefore lowering mitochondrial biogenesis through acetylation and deactivation of PGC-1, which will result in decreased mitochondrial oxygen consumption 34