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A study in the Journal of Clinical Biochemistry says, Vitamin B12 deficiency can cause big problems with nerves and blood. Vitamin B12 is key for making DNA, fatty acids, and energy. Source: Journal of Clinical Biochemistry Common Signs of Deficiency A Vitamin B12 shortage can show in many ways, like: Fatigue and weakness Numbness or tingling in hands and feet Difficulty walking Mood changes, such as depression Spotting these signs early is key for quick action

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[36] Antibodies to intrinsic factor and parietal cells cause the destruction of the oxyntic gastric mucosa, in which the parietal cells are located, leading to the subsequent loss of intrinsic factor synthesis

NAD+-dependent sirtuin activation in endothelial cells promotes antioxidant enzyme expression, reduces inflammatory responses, and enhances nitric oxide synthase activity, leading to improved endothelial function and vascular health