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Radiation has been shown to damage tumor vasculature and inhibit angiogenesis (Barker et al

The most concerning findings come from two trials using folic acid combined with 400500 g/day of B12: Ebbing (2009) found a statistically significant increase in overall cancer incidence (RR 1.21, CI 1.031.41) B-PROOF found an increased risk of colon cancer (HR 2.17, CI 1.263.75) in the per-protocol analysis (Oliai Araghi, 2019)

For metallothionein studies, four major human isoforms, MT1a, MT2, MT3, and MT4 were chosen (Table S1), though most experiments were conducted with MT2 due to its well-documented reactivity and Zn(II) binding affinity (Krel and Maret 2021)