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For the most part, withdrawal symptoms from benzodiazepines are uncomfortable but manageable

3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H 2 S 2 , H 2 S 3 and H 2 S

Over time, excessive oxidative stress may contribute to the cellular wear and tear associated with ageing

In fact, a key parameter omitted in the trials with deferiprone was that the iron chelator was not targeted to the mitochondria, so effectively only a small fraction of the compound delivered would accumulate in the principal site of damage under these conditions