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4.4 Application of non-pharmacological interventions in adjunctive treatment of depression While pharmacological treatment remains the cornerstone of depression management in PLWH, concerns regarding its potential adverse effectssuch as physical discomfort, sexual dysfunction, substance abuse, and overdose-related fatalitiesalong with the interactions between antidepressants and antiretroviral medications, and the risk of withdrawal and rebound phenomena, have prompted increasing interest in non-pharmacological treatments (131, 156)