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148 Thus, if the strength of the particular beneficial effect is the most important proof of the concept with the prostaglandins and other standard cytoprotectants, we have to admit that Roberts stomach cytoprotection/adaptive cytoprotection/organoprotection tolerates no recovery of the preexisting stomach lesions, providing only prophylactic effect

G.IazzettiF.SantamariaR.IraceC

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92 To reinforce this finding, a study involving CRC cells demonstrated that administration of aspirin reduced mTOR signaling by inhibiting the mTOR effectors S6K1 and 4E-BP1 along with modulation of the nucleotide ratios and activated AMPK in these cells