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Abstract Background Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophic lateral sclerosis (ALS)

[116] Endogenous opiate precursor theory [edit] In 1979, a possible association between autism and opioids was proposed, it was noted that injecting small amounts of opiates into young laboratory animals resulted in symptoms similar to those seen in autistic children

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In addition, some ROS such as ROOH can also be formed after the oxidation of different compounds such as lipids, proteins or DNA [15, 16]