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Much to our delight, however, the introduction of the electron-withdrawing substituent CF 3 (catalyst ( R )- 1d ) and C 2 F 5 (catalyst ( R )- 1e ), rather than the iodo-substituent of ( R )- 1c at the 3,3-position of the binaphthyl scaffold, resulted in a nearly complete conversion after the same reaction time, with excellent enantioselectivities (98% and 94% ee in entries 4 and 6, respectively)

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This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer progression will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or 2J2