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Interestingly, a few pathways remained dysregulated, opening important questions about the long-term prognosis of treated patients and warranting further exploration for potential complementary therapeutic strategies

2014;137(Pt 5):135060

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While the benefits of single antioxidant therapy may be limited and may even have negative effects, for example, long-term use of beta-carotene may increase the incidence of lung cancer in smokers (60), while vitamin E may increase the risk of bleeding in people with oral anticoagulants and even reduce the lipid-lowering effect of statins (61), Therefore, the safety and efficacy of long-term additional oral antioxidants deserve further exploration