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Table 1, although first-generation antifibrotic drugs, such as pirfenidone and nintedanibapproved over a decade agohave demonstrated efficacy in slowing IPF progression and improving survival rates in clinical trials, their benefits are constrained by significant side effects (e.g., nausea, diarrhea, and photosensitivity) that compromise long-term tolerability (King et al., 2011

MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus

252 SAM supplementation reverses GSH depletion, reduces mitochondrial DNA damage, and ameliorates steatosis and hepatocyte necrosis in ethanol-fed models

Physical characterization was performed via particle analyzer/zetasizer, electron microscopy [SEM/TEM] analysis and protein identification, quantification was performed by Western blot analysis for known EV markers of lysed EVs