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Eur J Surg Oncol (2014) 40(9):114350

If the doctor gives you local anesthetics, the pain should be tolerable

Between 4 and 18 months (usually around 6-12 months), parents notice: Loss of skills (stops babbling, stops reaching, loses social smile) Increasing irritability and inconsolable crying Sleep problems Loss of muscle tone (baby feels floppy) Seizures may begin This pattern normal development followed by regression with movement problems is highly suggestive of CFD

In particular, combination of optimized chemotherapy regimens with molecular or personalized treatment approaches could lead to development of improved treatments for CIPN with the promise to deliver improved patient outcomes