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But that flexibility demands precision

Celastrol Inhibits Hepatitis C Virus Replication by Upregulating Heme Oxygenase-1 via the JNK MAPK/Nrf2 Pathway in Human Hepatoma Cells

When this binding is inhibited, bile acid synthesis and secretion into the intestine continues, which leads to diarrhea (Farrugia & Arasaradnam, 2021)