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This is related to the Opc binding to fibronectin and vitronectin in the host serum, which act as a bridge for the connection with integrin 51 and v3, respectively

BlauveltAPappKAGriffithsCERandazzoBWasfiYShenYKet al

lowest tolerated dose Phase Step 2 Weeks Weeks 5-8 Cagrilintide Dose 0.5 mg/week Purpose Dose escalation Phase Step 3 Weeks Weeks 9-12 Cagrilintide Dose 1.0 mg/week Purpose GI side effects often peak here Phase Step 4 Weeks Weeks 13-16 Cagrilintide Dose 1.7 mg/week Purpose Approaching maintenance Phase Maintenance Weeks Weeks 17+ Cagrilintide Dose 2.4 mg/week Purpose Target dose used in late-stage study protocols Each step lasts 4 weeks

Petrov VA, Saltykova I V, Zhukova IA, Alifirova VM, Zhukova NG, Dorofeeva YB, et al