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In general, the probe should be absorbed exclusively via the paracellular pathway, be metabolically inert and freely filtered at the glomerulus without tubular reabsorption ( The most commonly used test evaluates the differential urinary excretion of the disaccharide lactulose and the sugar alcohol mannitol

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Andersson, Emmanuel Shapira, Biochemical and clinical response to hydroxocobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC), The Journal of Pediatrics, Volume 132, Issue 1, January 1998, Pages 121-124, ISSN 0022-3476, Okuda K, Yashima K, Kitazaki T, Takara I