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Gastroenterology 159 , 8195 (2020)

As the most widely studied member of the SIRT family, SIRT1 regulates cell biology and metabolism by deacetylating histones or a variety of other cytoplasmic substrates and by inhibiting pro-inflammatory kinases or regulating transcription factors, such as nuclear factor B P65 (NF-B P65) and P38 mitogen-activated protein kinase (P38 MAPK) [14,15,16]