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Previous studies have shown that pyroptosis mediates a variety of downstream effects by activating caspase-1 through the canonical pathway or caspase-4/5/11 through the noncanonical pathway [9]

It is not intended, packaged, or labeled for human injection, veterinary application, or any clinical use

lot 158670) at a 1:10,000 dilution as primary and secondary antibody, respectively

Glioma clumps formed by GBM lead to the upregulation of Piezo1 expression, which, in turn, promotes the rapid proliferation and invasion of glioma cells, accelerates the spreading range and speed of the clumps, and creates a vicious cycle (Velasco-Estevez et al., 2020), and changes in mechanical forces may lead to the activation of Piezo1 channels, exacerbating ischemic brain injury (Zhou et al., 2020)