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Moreover, unbound volume of distribution in the brain parenchymal cells (V u,cell ) estimated using the brain homogenate method and cerebral microdialysis can be combined with V u,brain to estimate unbound (pro)drug concentration ratio in intra- and extracellular compartments of the brain (K p,uu,cell ) (87)

doi: 10.1038/s41392-021-00470-1 133 KangI.ChangM

Notably, the cold-induced white-to-brown conversion was demonstrated to arise also when the adrenergic cascade is blocked, highlighting that white adipocytes directly sense temperature variations 54

If you have diabetes or take blood-sugar-lowering medications, alpha lipoic acid may affect glucose levels