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21,26 The biomechanical balance of loading and unloading the spinal column contributes significantly to the IVD metabolism, and alterations in this balance lead to unfavorable changes in the cellular matrix, resulting in disc degeneration

Oxid Med Cell Longev 2013:575482 Moi P, Chan K, Asunis I, Cao A, Kan YW (1994) Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region