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Additionally, UA promotes skeletal muscle angiogenesis through modulation of the silent information regulator 1 and peroxisome proliferator-activated receptor-gamma coactivator-1-alpha signaling pathways, resulting in increased capillary density and improved muscular endurance (8)

At baseline, trained nurse interviewers administered a structured questionnaire to each subject to collect comprehensive information on demographics, occupation, lifestyle habits, medical history, usage of medication and dietary supplements, alcohol consumption, and past cigarette smoking history

However, in the evaluation of adverse reactions, the incidence of neutropenia in Japanese patients was higher than that in Western patients (76, 77) Thus, a randomized, multicentre, double-blind phase 3 RAINBOW-Asia trial (78, 79) (a bridging study similar to RAINBOW) was initiated, in which patients were randomized to receive ramucirumab plus paclitaxel (n=294) or placebo plus paclitaxel (n=146), the primary outcome was (mPFS 4.14 months vs 3.15 months, mOS 8.71 months vs 7.92 months), and the most common adverse reaction was also decreased neutrophil count (54% vs 39%)