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The peptide appears to exert a protective effect through modulation of the dopaminergic and serotonergic systems, as well as through reduction of oxidative stress

Our recent study on 2A R-D 4 R heteromers brings together two key receptors involved in the pathogenesis and treatment of ADHD, since 2A R-D 4 R heteromers represent a significant population of both catecholaminergic receptors in the mouse cerebral cortex ( 6 D 4 R antagonists as a plausible treatment for ADHD and other impulse-control disorders Apart from the association with D 4.7 R, several other preclinical and clinical findings converge on the involvement of D 4 R and its heteromers in ADHD and other impulse-control disorders and, therefore, on its possible utility as a therapeutic target for those disorders

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Blood 139 , 20502065 (2022)