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4.2.2 Osteogenic transformation of VSMCs Vascular smooth muscle cells undergo an osteogenic transformation in CKD-MBD, driven by immune signals and uremic conditions, culminating in VC

Functional assays confirm that the overexpression of miR-144-5p enhances the protective effects of BMSC exosomes against GC apoptosis, whereas the inhibition of miR-144-5p reverses these benefits

Low stomach acid, small intestinal bacterial overgrowth, and chronic parasitic, fungal, or bacterial infections in the gut all contribute to leaky gut and INFLAMMATION, both of which in turn can trigger or exacerbate autoimmune thyroid disease

This accumulation of the damage over time and across tissues is a primary risk factor in the genesis of many age-related diseases, such as cardiovascular disease (CVD), cancer, neurodegeneration, diabetes, osteoporosis, and sarcopenia [1, 2]