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For example, RASSF1A, a key node linking the Hippo and RAS signaling pathways, frequently undergoes promoter hypermethylation in renal cell carcinoma and lung cancer [84, 85]

15,16 Recently, these concurrent exogenous and endogenous hits have been investigated as potential therapeutic targets

Compared to the unstressed samples, the expression of all RcGPXs was not significantly changed under cold stress in leaves, while that of the only RcGPX5 was significantly downregulated in roots, and RcGPX2 and RcGPX4 were dramatically upregulated in stems after cold treatment