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FIGURE 5 3.5 Nitazoxanide reduced the mRNA expression of ER stress markers in rats with MTX-hepatotoxicity To determine whether the hepatoprotective effects of NTZ against MTX-hepatotoxicity are associated with ER stress reduction, mRNA expression and the protein level of ER stress markers were determined in liver homogenates

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We observed that expression of the oligodendroglial lineage marker, oligodendrocyte transcription factor 2 (OLIG2) co-labeled with Ki67 increased substantially in the CPZ + 40HZ group (Fig