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25Hydroxycholesterol is reported to play a regulatory part in the biosynthesis of sphingomyelin, which is required with cholesterol for the formation of raft sub-domains in membranes, where signalling molecules are concentrated, and together with other oxysterols, such as 24 S ,25-epoxycholesterol, to regulate the hedgehog proteins in embryonic development

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Cancer, atherosclerosis, autoimmune diseases, diabetic cataracts, inflammatory bowel disease, nutrient deficiencies, premature aging, and viral infections can all be linked to free radical damage

10.1016/j.tcb.2022.02.003 10 BielecB.SchuefflH.TerenziA.BergerW.HeffeterP.KepplerB