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A week after Visit 6, participants were contacted by phone to ensure that they had not experienced any adverse events since the last visit

doi: 10.3389/fmicb.2024.1426911 Received 02 May 2024 Accepted 26 July 2024 Published 07 August 2024 Volume 15 - 2024 Edited by Shaohua Wang, Ohio University, United States Reviewed by Laura Mitrea, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Romania Zhiyuan Pan, Grand Life Sciences Group Ltd., China Updates Copyright 2024 Zhu, Yan, Fang, Fan, Sun, Zhou, Zhang and Shi

To date, creatine supplementation has been shown to be neuroprotective in many cellular and animal models of neurodegenerative diseases including Huntingtons disease (HD), Alzheimers disease (AD), Parkinsons disease (PD), and amyotrophic lateral sclerosis (ALS) (Figure 3