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Translationally, efforts should focus on screening metabolic biomarkers for early diagnosis and prognosis, designing precision drug delivery systems targeting metabolism (potentially combined with immunotherapy or antibiotics), and exploring combined metabolic intervention-microbiota regulation strategies for prevention

34 In humans, age-associated decreases in reduced or total glutathione have been found in several studies

Concurrently, the individual experiences a diminishing ability to control their alcohol consumption, leading to frequent episodes of excessive drinking

doi: 10.3389/fgene.2023.1118391 374 LiuLLianNShiLHaoZChenK