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doi: 10.1111/joim.13368 6

To examine the impact of changing seasonality over the historical period, we isolate the impact of precipitation and 18 O seasonal changes, recorded in the ensemble mean, on the precipitation-weighted 18 O between the first 50 years of the simulation and the last 50 years of the simulations (see Liu and Battisti, 2015

The limitations of this study include that the experimental findings were primarily derived from a rat model of acute myocardial ischemia, which may not fully replicate the pathophysiological complexity of human cardiovascular disease, potentially restricting the direct clinical translatability of the results