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Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation ( via O-glucuronidation (50%70%) and O-sulfation (approximately 25%) pathways and forms the corresponding conjugates that can be easily excreted by the kidney

Mechanism of Action Cofactor for Enzymes : Selenium is required for the activity of glutathione peroxidase, an enzyme that utilizes glutathione to neutralize hydrogen peroxide and other harmful compounds

However, the virulence factor Hpt (a glucose-6-phosphate permease) mediates fosfomycin uptake, conferring antibiotic susceptibility during infection ( 3.1.2 Fosfomycin target modification Modification of the antibiotic target MurA constitutes another mechanism leading to fosfomycin resistance

Epub 2016 Jan 29