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Description

Structure-guided spike design has also been used to identify artificial substitutions in the spike sequence that can increase the expression, solubility, and stability of spike (termed HexaPro) for use as a vaccine antigen [165, 166]

Specifically, these benefits may be dependent on enhanced PINK1/Parkin-mediated mitochondrial autophagy and improvements in the antioxidant capacity of the liver via SIRT3 regulation [68]