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Neurology 73:805811 Parvizi J, Anderson SW, Martin CO et al (2001) Pathological laughter and crying: a link to the cerebellum

Second, the methylation of a regulatory region of DNA recruits methylated DNA binding proteins such as MeCP2, which is a methyl binding protein expressed in neural precursors and stem cells, and chromatin modification enzymes such as HDACs to the gene [14,15,16,17] which, in turn, introduce histone modifications resulting in the silencing of chromatin

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