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Therefore, it will be worthwhile to assess the therapeutic potential of antioxidants and modifiers of redox regulation in TDP-43, C9ORF72, and FUS models of ALS in the future

Silibinin inhibits the production of pro-inflammatory cytokines through inhibition of NF-kappaB signaling pathway in HMC-1 human mast cells

Other contributing factors may include genetic predisposition, environmental triggers, or a combination of both

48 Deep learning predicts that gut microbiota metabolites can influence the activation or inhibition of oxidative stress pathways (such as Nrf2/KEAP1 signaling pathway) in AD through binding to host G-protein-coupled receptors