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[3] Hyperpigmentation in B12 deficiency occurs as a result of (1) decreased levels of reduced glutathione which activates tyrosinase and results in increased melanin synthesis, (2) defect in transfer of melanin from melanocytes to keratinocytes resulting in pigment incontinence, (3) increased biopterin in B12 deficiency increases hydroxylated phenylalanine which results in hyperpigmentation

Collagen production naturally declines with age, and the rapid volume reduction can leave many individuals with loose, sagging skin that diminishes their satisfaction with otherwise successful weight loss outcomes

An intramuscular injection (IM injection) is a medical technique used to deliver medication directly into muscle tissue, where it can be absorbed quickly into the bloodstream

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