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If you're experiencing persistent fatigue, unexplained weight loss, or severe physical or neurological weakness, you may be suffering from Vitamin B12 deficiency

B vitamins in general can produce a mild energising effect, and some patients find taking them late in the day affects sleep

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The MTHFR gene has been found to have 15 rare variants that are linked to severe enzyme deficit and one common mutation, C677T, that is linked to a lesser enzyme deficit, according to research by Goyette et al