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However, high-dose oral therapy (10002000 micrograms daily) may be considered in specific circumstances, such as confirmed dietary deficiency in vegans without malabsorption, though this requires specialist assessment

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Natural materials such as chitin, gelatin, and alginate have also been used to produce hydrogels like chitosan and gelatin methacryloyl (GelMA) that act as scaffolds and promote ECM production (Guo et al., 2014