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Two cytosolic enzymes, GCLC/-GCS (glutamate-cysteine ligase catalytic subunit) and GSS (glutathione synthetase), sequentially catalyze the synthesis of GSH from glycine, cysteine and glutamate in the presence of adenosine 5-triphosphate/ATP (Figure 3) [84]

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Additionally, when used in young mice, CAR-T cells were able to persist at considerable levels for up to 12 months post initial treatment and limit the onset of metabolic and physical disorders later in life