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FIGURE 9 Discussion Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease characterized by a complex pathogenesis involving multiple interrelated processes, including intestinal barrier disruption, oxidative stress imbalance, excessive inflammatory activation, gut microbiota dysbiosis, and metabolic disturbances ( Body weight loss, colon shortening, and histological damage are hallmark pathological features of the DSS-induced UC model and serve as key metrics for evaluating therapeutic interventions