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Food and Chemical Toxicology, 151 , 112145

Patients and clinicians often misinterpret the neurologic signs and symptoms of vitamin B12 deficiency as those of diabetic neuropathy.2 Also, vitamin B12 deficiency can increase the severity of peripheral neuropathy in patients with T2DM.6 In addition to memory impairment, neurocognitive symptoms attributable to B12 deficiency include confusion, personality changes, delirium, and depression

A 2021 review published in Nutrients found that GLP-1 receptor agonist use was associated with reduced dietary intake of multiple micronutrients including B12, particularly in patients following calorie-restricted eating patterns, supporting the rationale for monitoring B12 status during treatment even in patients without pre-existing deficiency risk factors