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A high-sugar diet appears to raise the risk of kidney stones, which may relate in part to the ability of refined sugar and large quantities of carbohydrate to elevate urine calcium (Thom 1978

PLoS One 11 (9), e0162717

In parallel, luteolin enhances apoptosis in aberrantly proliferative tissues through activation of caspase-3, -8, and -9, disruption of mitochondrial membrane potential, and induction of DNA fragmentation ( 5.4 Modulation of the PI3K/AKT/PTEN survival and metabolic pathway The PI3K/AKT/PTEN axis integrates metabolic control, cell survival, and growth factor responses in reproductive tissues ( 5.5 Modulation of estrogen and progesterone receptor signaling Hormonal balance depends on coordinated estrogen and progesterone signaling