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Selenium supplementation was observed to enhance the endogenous antioxidant potential of trophoblasts, and help safeguard against tissue injury associated with ferroptosis [101], contributing to the prevention and treatment of GDM [100]

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Transcriptomic analysis revealed significant differences between expression signatures of Nrf2 WT and KO cells, showing 1,566 up-regulated and 5,272 down-regulated genes in the Nrf2 KO condition compared with the WT (Fig 6A)

Leaky gut syndrome has been implicated as a factor in many medical conditions, including celiac disease, Crohns disease, Irritable Bowel Syndrome (IBS), and some autoimmune diseases, though whether it is a cause or consequence of those diseases remains unclear