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Lanperisone another recently identified oncogenic RAS-selective lethal small molecule that causes non-apoptotic, iron-dependent death in mouse Kras-mutant tumor cells (Shaw et al., 2011), may also inhibit the function of system x c or another target in the ferroptotic pathway

While some foods like spinach, avocado, and asparagus contain small amounts of glutathione, the body mostly produces its own

A study involving 20 men has found that 8-week aerobic exercise (treadmill training, 40 min, 3 times/week) significantly decreases serum ROS and neuron-specific enolase (NSE) levels, and increased SOD activity and brain-derived neurotrophic factor (BDNF) levels while improving body composition parameters in obese individuals, indicating that exercise can exert beneficial effects through improving the oxidant-antioxidant imbalance disrupted by obesity, elevating levels of neurotrophic factors, and limiting blood-brain barrier dysfunction [180]

10.1016/j.chroma.2017.05.062 146 WangY.TianY.ZhangN.LiX.WangX.WangW.et al (2021)