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It has been shown that even peptides, despite often being unstable during digestion, may still induce sensitization

Studies in presymptomatic ALS mice have shown that neuronal stress leads to microglial activation and T cell entry, indicating the immune system is engaged early in the disease course (98, 99)

384,385 The CAPItello-291 phase 3 study indicates that regardless of AKT pathway abnormalities, the capivasertib plus fulvestrant group demonstrates a significant advantage in median PFS compared to the placebo plus fulvestrant group