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Although istradefylline was associated with a significantly higher risk of dyskinesia compared to placebo (RR = 1.72, 95% CI = 1.26 to 2.34, p = 0.0007), no significant differences were observed for mild adverse reactions such as tremor, nausea, constipation, hallucinations, insomnia, somnolence, or accidents

In clinical contexts, AOD 9604 has also been evaluated in obesity-related trials, where ongoing work continues to assess its potential role

One study used molecular dynamics simulation tools to investigate the impact of 4 forms of last-generation graphene-based nanostructures on preventing -synuclein amyloid fibrillation