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Name: body health glutathione Treatments 101: Part 1 — The Mother of All Antioxidants Glutathione Benefits: Top Uses for
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What Really Drives Spinal Aging

doi: 10.1038/s41564-025-02001-y 59 ChoiH.LeeJ.ChangY

In cells exposed to hypoxia or ischemia, hypoxia-inducible factor-1 (HIF-1) is upregulated and acts as a key regulator of more than 70 genes, including TNF- , IL-1 , IL-6 , and IL-12 , promoting their expression to potentially harmful levels [15]