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Then one morning you wake up with a face (or back, or chest) that looks like you're 16 again

Several factors increase your likelihood significantly: History of GERD or acid reflux , even if it was well-controlled before starting tirzepatide Hiatal hernia , which already weakens the lower esophageal sphincter Obesity , which increases abdominal pressure (though this improves as you lose weight on the medication) Smoking , which relaxes the esophageal sphincter Certain medications like NSAIDs, calcium channel blockers, or bisphosphonates that independently increase reflux risk Eating large meals or eating close to bedtime If you had occasional heartburn before starting tirzepatide, the medication can amplify it significantly during the early weeks

When you're trying to answer a difficult, often moving-target objective, the last thing you should have to worry about is the integrity of your tools

After reconstitution, refrigerate at 28 C and use over a matter of weeks rather than months