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Centrifuge at 12,000 rpm for 10 minutes at 4 C to remove insoluble particles

Southern Thoracic Surgical Association's 53rd Annual Meeting

Moreover, topiramate, an anti-epileptic drug that provides neuroprotection by preventing glutamate toxicity, has antidiabetic and beta-cell cytoprotective effects [129] and long-lasting remission was observed in a T1D patient after treatment with topiramate for generalized seizures [130]

Mutations in this region have also been widely observed in many types of tumors, including colorectal cancer [22, 69], lung cancer [65], testicular germ cell tumor [117], hepatocellular carcinoma [98] and gastric cancer [78]